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ROS levels must be well controlled, since elevated ROS has been shown to have deleterious effects on osteoblasts

Chnh v th kt qu s dng ca glutathione c th s khc nhau

However, we cannot assume that we have optimal levels of glutathione at all times

Luck AN, Mason AB

Long-term HFD consumption increased hepatic IKK- glutathionylation and NF-B suppression The mechanistic investigations in our cell culture studies provided evidence suggesting that intracellular GSSG accumulation sensitizes hepatocytes to TNF cytotoxicity via the induction of IKK- glutathionylation, leading to reduced IKK- phosphorylation and subsequent NF-B suppression

A practical guide to methods controlling false discoveries in computational biology