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For users in a caloric deficit, this is not a minor consideration

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Better recruitment, retention and analysis to ensure safety and effectiveness in populations historically under-represented in studies and generally suffering from health inequities is a minimal first step to enhance health justice by sex, race/ethnicity and nationality, etc

Whether the kidney benefits of GLP-1s persist over five to ten years will shape long-term confidence, and payers will ultimately decide how broadly those benefits can be accessed

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A theoretical concern in research pertains to copper homeostasis: since GHK-Cu delivers copper ions, copper status should be monitored during extended research protocols