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Comparison to Other Routes Intravenous: 100% bioavailability (by definitionthe full dose enters circulation) Subcutaneous: Likely 6090% bioavailability (depends on absorption rate) Oral: ~38% systemic bioavailability This is why some researchers hypothetically prefer injected routeshigher bioavailability means lower nominal doses are needed
Louandre C, Marcq I, Bouhlal H, Lachaier E, Godin C, Saidak Z et al
A., Lima, K
It allows for more pronounced effects to be observed over a shorter timeframe
Most peptides break down within minutes in the acidic environment of the stomach
Bottom line: Route of administration and regulatory status matter here more than usualand most online discussions gloss over both
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