Samman S, Naghii MR, Lyons Wall PM, Verus AP (2013) The nutritional and metabolic effects of boron in humans and animals

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Modern clinical research has shown that saffron supplementation (typically 2050mg per day) can improve visual acuity, retinal function, and contrast sensitivity in adults with AMD.58 These effects are attributed to compounds called crocin and crocetin, which may enhance retinal blood flow and protect photoreceptor cells from oxidative stress
In non-alcoholic steatohepatitis (NASH)the inflammatory form of NAFLDthis anti-inflammatory potential may be particularly relevant, though clinical evidence remains limited