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The easiest place for self-administration of the IM injections is in the middle third of the vastuslateralis muscle of the thigh

Of equal concern is the fact that unregulated peptides may be contaminated with impurities, according to the FDA

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However, numerous patients have reported benefit while others have reported no benefit

This reflects the biological chronicity of obesity: the hypothalamic set-point for body weight, appetite hormone profiles (including leptin and ghrelin), and resting metabolic rate tend to revert toward pre-treatment baselines once pharmacological GLP-1 stimulation is removed