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It is one of the major endogenous antioxidants directly involved in the reduction of reactive oxygen species (ROS), as well as maintaining the levels of exogenous antioxidants such as vitamins C and E [read more about glutathiones many functions here]
Alcoholic Liver Disease (ALD) is the result of the way our body treats alcohol in the liver where alcohol metabolic products lead to the formation of Reactive Oxygen Species (ROS) that harm cells through interacting with fats, proteins, and DNA
Other symptoms of zinc toxicity include headaches, fatigue, and disruptions in lipid metabolism [92,93,94]
S.et al (2012)
Neutralizing IL-1 or IL-18 (the inflammasome products) is another approach: Anakinra (IL-1 receptor antagonist) has been used off-label in systemic inflammation settings and is attractive for short-term use around surgery to DAMPsen the IL-1 surge (115)