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Brain Res 537:298302
Provider Perspective Dr
Because it competes at the nicotinamide substrate site rather than the SAM cofactor site, it is also used as the substrate-competitive reference compound against which bisubstrate and covalent NNMT inhibitors are benchmarked
The caution: daily stimulant laxative use can lead to dependency, where the colon becomes reliant on the stimulant to function
Best candidates Those with gut healing goals represent the strongest candidate pool
PMID: 39265666 | doi:10.1016/j.arthro.2024.09.005 Lee E et al
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