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Study participants We identified all adult (aged 20 years) patients with NAFLD and type 2 diabetes who had newly started treatment with non-insulin glucose-lowering drugs (metformin, GLP-1RAs, SGLT2 inhibitors, sulfonylureas, meglitinides, thiazolidinediones, acarbose or dipeptidyl peptidase-4 inhibitors) between 1 January 2013 and 31 December 2021
PMID: 33341227
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H., Yarov-Yarovoy, V., Gutman, G
C.KunzM.GomesF
Furthermore, poor solubility poses significant hurdles for formulation development, frequently resulting in low oral bioavailability and necessitating complex nanocarriers or specialized formulations that increase cost and limit administration routes [68,69,70,71]
In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions
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