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In the subchondral bone of ovariectomy-induced OA (OVX-OA) rats, Sparc secreted by osteoblasts downregulates the AMPK/FoxO3a signaling pathway in chondrocytes, promoting cartilage degeneration through intercellular communication (83)

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Semin Cell Dev Biol 115:3744

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Nooms Commitment to Addressing the Individual Needs of Patients: The most trusted obesity care guidelines recommend that GLP-1s be used in combination with a reduced calorie diet and increased physical activity for best results

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