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After 52 weeks, tirzepatide reduced the composite endpoint of cardiovascular death or worsening heart failure events by 38% compared to placebo

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ICER gave semaglutide and tirzepatide their highest value rating for obesity vs diet alone

The inducers are: (1) ACSL4, as a major regulator in the pathophysiology of ferroptosis, which stimulates it by increasing the content of long PUFAs and omega-6 PUFAs in the cell membrane ( Research Progress Into Ferroptosis in Ophthalmology The clinical application of ferroptosis is currently mainly being studied in terms of nervous system diseases, tumors, and ischemia/reperfusion injury