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P values were calculated using a two-tailed Students t-test ( g ) one-way ANOVA ( b, d, e, i )

GLP-1R activation produces glucose-dependent insulin secretion, glucagon suppression, delayed gastric emptying, and central appetite reduction through hypothalamic and brainstem signaling

This makes it an easy alternative to Ozempic as users are less predisposed to anxiety, depression, and any other personality changes

What compounded versions lack is FDA approval of the specific finished drug product, which is granted to Novo Nordisks proprietary formulation and delivery device, not to the semaglutide molecule itself

Highlights of Prescribing Information for Ozempic (Semaglutide) [PDF]

Author contributions D-DW, S-MH, PZ, and Q-LW conceived and designed the study