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It can lead to permanent vision loss if untreated
Journal of Radiation Research and Applied Sciences
If additional glycemic control is needed: Increase to 9 mg orally once a day
Secondary Outcome: Secondary Outcomes: Changes in waist circumference, body fat, body lean mass, and metabolic risk factors including levels of plasma glucose, insulin sensitivity, serum lipids, and blood pressure Statistical Analysis Full details previously published 2 and can also be found in the STEP group statistical analysis plan at NEJM.org Statistical analysis approach sought strong control for type I error All endpoints addressing intervention efficacy were analyzed using intention-to-treat approach All endpoints addressing intervention safety were analyzed using per-protocol approach Efficacy endpoints analyzed using 2 estimands Treatment Policy Estimand: intention to treat analysis
In this context, GLP-1 receptor agonists represent one of the most promising pharmacological classes, particularly if challenges related to cost, equitable access, reimbursement policy, and supply constraints are addressed
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