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These Authors failed to evidence significant changes in indexes of insulin resistance and speculated that other classical effects of GLP-1 RA, such as suppressed glucagon secretion, with consequent reduced hepatic glucose production, could have been involved in the improvement in glucose metabolism and ectopic fat deposition [54]
71-73 H
Many peptide vials are sealed under vacuum during manufacturing
Limitations of current evidence include small sample sizes, short study durations, heterogeneous patient populations, and varying dosing regimens
As indicated in this review, there are several ongoing trials in this area that will hopefully shed light on the use of these new agents in critically important patient populations at elevated risk of CV morbidity and mortality
Adverse effects included nausea and vomiting, excessive weight loss in patients with T2DM, and hypoglycemic events in combination with conventional hypoglycemic agents
