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This means the higher the dose, the more weight loss will be seen for most patients if they are responsive to the medication in general

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It is the mathematical consequence of approaching a limit (steady state)

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In people with diabetes, particularly those with heart or kidney disease, these medications improved blood sugar levels, lowered the risk of heart and kidney complications, supported weight reduction, and reduced the risk of early death

Without it, old eating patterns can return more easily than after a purely behavioural intervention