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Owing to its -helical binding conformation, GLP-1 stroke us as both a good model for testing -helix mimicry with oligourea foldamers and a relevant pharmaceutical target

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Zhang et al., 2022) have found that incretin receptor agonists (Exendin-4 and DA-JC4) and GLP-1/GIP dual receptor agonists DA5-CH can successfully cross the blood-brain barrier and reach the pathological area of PD, which is expected to become an ideal therapeutic drug

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