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A newer GLP-1 receptor agonist, tirzepatide, demonstrates weight loss as high as 20% change in body weight compared with 3% in the placebo group in a RCT

Subsequently, 22 peptides (50% of the shortlisted peptides) with a confidence score 0.92 were superimposed in the context of GLP-1 bound to GLP-1R (Figure 7)

Some studies have suggested that brain regions with a high degree of functional connectivity are energy efficient and can minimize consumption of glucose [27, 51, 52]

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