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Oxidative phosphorylation is disrupted at complex I and II in GSH-deficient follicular B cells To determine whether the accumulation of succinate in Gclc -deficient FoB was caused by a dysfunctional ETC, we assessed the respiratory parameters of each ETC complex

Benefit 7: Skin Health & Cancer Prevention Pollutants, UV radiation and other environmental factors induce oxidative stress which leads to the breakdown of collagen and, in some cases, lead to skin cancer

Moreover, our reliance on specific functional assays, such as flow cytometry and Seahorse metabolic analyses, will be complemented in the future by spatial metabolomics-based approaches to elucidate the molecular mechanisms of TMQ0153 comprehensively

PMID: 47 HurrellBPSakanoYShenSHelouDGLiMShafiei-JahaniPet al

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