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However, in diseases such as T1DM, psoriasis, autoimmune hepatitis, and vasculitis, studies have also suggested that amino acid metabolic reprogramming may participate in the regulation of macrophage function and may exhibit directional effects and context-dependent differences that vary with tissue niche, stimulus spectrum, and disease stage (59, 8082)

Patients can remain on these medications indefinitely, and the clinical data supporting long-term use extends to multiple years

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