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In three nested casecontrol studies from England and Wales, involving 440,089 patients with T2DM and without ASCVD treated with non-insulin glucose-lowering medication, combined SGLT2i and GLP-1RA therapy used for primary prevention was associated with 30% lower odds of MACE (defined as myocardial infarction/acute coronary syndrome, stroke/transient ischemic attack, and/or cardiovascular death) compared with other combination regimens (OR, 0.70
What is pernicious anemia and why do you need B12 injections if you suffer from it
mice deficient in NLRP3 exhibit increased susceptibility to systemic candidiasis (Loh and Lam, 2023)
(Prior trials of injectable GLP-1-based therapies showed ~ 16% loss with semaglutide and ~21% with tirzepatide)
Despite the overly-simple good/bad labels, both HDL & LDL Cholesterol play vital roles in nervous system health, immune system repair, production of digestive acids and the production of fat-soluble vitamins
Pharmacol Ther 2007;113:3:546-93
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