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Int J Nanomed 8:45074520 Azam F, VV Prasad M, Thangavel N (2012) Targeting oxidative stress component in the therapeutics of epilepsy

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Studies show the compounds molecular structure allows for specific nuclear receptor engagement, different from peptide based substances

Depletion of mitochondrial glutathione has been associated with increased neuronal injury and has been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimers, Parkinsons, and multiple sclerosis

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Additionally, the translational relevance of these findings likely differs by disease phenotype