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GLP-1 is produced in the cells lining the intestines, which makes gut health important

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Tirzepatide induces substantial weight losstypically 5-10% in type 2 diabetes and 15-20% in obesity without diabetes at therapeutic doseswhich can directly reduce cardiac workload and peripheral vascular resistance

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This helped patients get the treatment they needed without stopping, although its not known how well oral tirzepatide works