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Efficacy analyses were performed on two sets: the full analysis set, defined as all unique randomized patients grouped according to the treatment assigned at randomization, thereby following the intent-to-treat principle, and an on-treatment analysis, defined as all exposed patients while they were receiving treatment (that is, had received at least one dose in the previous 35 d), grouped according to the treatment that they received

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It is important to emphasise that these potential benefits are largely theoretical or extrapolated from separate studies, rather than proven through robust clinical trials of the combination

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Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance

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Most patients report significant symptom reduction within 30 to 45 minutes of the session

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