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Absolute contraindications include: Active malignancy of any kind (GH and IGF-1 are growth-promoting signals) Active diabetic retinopathy (IGF-1 may worsen retinal vascularity) Pregnancy or breastfeeding Known hypersensitivity to any component of the formulation Pituitary tumours or untreated hypothalamic disease Relative contraindications requiring careful evaluation include pre-existing insulin resistance, type 2 diabetes, uncontrolled cardiovascular disease, and sleep apnoea (GH elevation can worsen upper airway tone in susceptible individuals)
Selective GH Stimulation: Unlike other GH-releasing peptides (e.g., GHRP-2, GHRP-6), Ipamorelin selectively induces GH release without significantly elevating cortisol or ACTH levels, even at doses up to 0.03 mg/kg, offering a cleaner endocrine profile
At lower doses, GLP-1 helps regulate cravings, reduces late-night snacking cycles, and supports a mild caloric deficit without tanking energy levels
placebo (0.97 vs 1.56 ml/min/1.73 m 2 per year, p 100 mg/g and consistently reduced UACR progression in patients with various degrees of albuminuria [23]
