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As a 2022 report noted, "obesity remains the most important risk factor for the incidence and progression of osteoarthritis." According to Bliddal, the researchers launched the study to answer this question: "Would a highly effective anti-obesity medication improve KOA to a clinically meaningful degree?" Other studies had tackled the question with inconsistent results, he said

The mean percentage of BrdU-labeled cells for three cultures per treatment was used as an indicator of activation (entry into the cell cycle) and the subsequent proliferation activity of plated satellite cells, according to Tatsumi et al

Acknowledgements This work was supported by UREKA Sarl, Immupharma Group