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By slowing gastric emptying and acting directly on brain receptors that regulate hunger, these medications significantly reduce food intake
Semaglutide and GLP-1 medications mimic hormone receptor agonists known as glucagon-like peptide-1 agonists
NICE restricts semaglutide to BMI 35 kg/m, shrinking the eligible population by 60% relative to FDA criteria [3]National Institute for Health and Care Excellence, Semaglutide Guidance, nice.org.uk
A patient who loses 15% of body weight on tirzepatide over the next 18 months will enter a retatrutide program, if they choose to transition, from a metabolically stronger position than one who waited
GLP-1 RAs have also demonstrated cardioprotective effects by reducing the risk of major cardiovascular events, such as heart attacks and strokes, in individuals with T2DM
doi:10.1038/s41380-019-0426-0 115. Song, Y., Zllner, H
