Metsera is exploring a range of weekly doses for its Phase 2b trials in obesity (with or without T2D separately), and looks to find the optimized weekly dose for both efficacy/tolerability
The effect of a high-MUFA, low-glycaemic index diet and a low-fat diet on appetite and glucose metabolism during a 6-month weight maintenance period
4mg/3mL (1.34 mg/mL) & 8mg/3mL (2.68mg/mL) and WEGOVY: 0.25 mg / 0.5 mL
In contrast, Noom states that their dosing starts at 25% or less of the standard 0.25 mg dose and escalates at a personalized rate. While microdosing GLP-1 medications may provide a more personalized experience, there are still questions regarding the safety of this practice as there are currently no published studies on the process, and the microdoses may come from a compounding pharmacy
For next-step supplementation, see supplements to lower cortisol
It depends on your individual health goals, preferences, and readiness