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human evidence is limited and individual results vary
Despite the favorable CYP profiles for some of the compounds, all five molecules triggered at least one PAINS alert that was most associated with catechol_A substructures
Neither mechanism directly stimulates insulin secretion in a glucose-independent manner, making the combination inherently safer regarding hypoglycaemia compared to sulphonylureas or insulin
No claim relies on a single uncontrolled study or marketing-only content
753483) and were maintained at 37 C in a humidified incubator with 5% CO 2
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