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Indeed, IFN-mediated protein ISGylation regulates the ubiquitin-proteasome system to increase cellular ROS
(2025): 10.4081/monaldi.2025.3159Online ahead of print
This difference may be due to different cell lines different responses to MSTN
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At the molecular levels, HSCs express the genes which encode for enzymes such as matrix metalloproteinase (MMP)-1 (interstitial collagenase) (Casini et al., 1994), which digests native fibrillar collagen types I and III, and MMP-2 (Milani et al., 1994), which digests denatured collagen types I and III and native collagen type IV, as well as tissue inhibitors of MMPs (TIMP)-1 and TIMP-2 (Iredale et al., 1992)
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