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The latter route has a large advantage of adding circulation time to the drug, allowing long-lasting effects of the drugs, potentially reducing the administration frequency and possibly also lowering gastrointestinal complications, as currently only subcutaneous and very few oral routes have been explored

doi: 10.1007/s00125-017-4354-8 132 SammsRJCoghlanMPSloopKWSammsRJCoghlanMPSloopKW

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Comparative example 1 preparation of semaglutide by standard Fmoc solid phase peptide Synthesis procedure The synthesis of semaglutide was completed using standard Fmoc solid phase peptide synthesis, i.e., using standard Wang Resin, following the same synthesis procedure as described in examples 3-22 above, and the final resulting crude semaglutide peptide had an HPLC purity of 36.7% (fig

Mashayekhi, M., Nian, H., Mayfield, D., Devin, J