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Some individuals reach a weight loss plateau on tirzepatide despite dose optimization, prompting exploration of alternative mechanisms like single-pathway GLP-1 activation

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If symptoms persist beyond six weeks or steadily worsen, that is not purging

They do not require a BMI threshold for enrollment

Increase fiber strategically Soluble fiber slows gastric emptying and promotes satiety through mechanisms that stack with tirzepatide effects

Understanding how diet and nutrition affect these pathways may provide important new information on effective MDD treatment strategies