If a quick onset is required, Immediate Release is the best option
When to seek medical help See a doctor promptly if you have spreading redness or warmth around the site, discharge or a fever, numbness or weakness that does not settle, or any swelling of the face, lips or throat or difficulty breathing, which can signal a rare allergic reaction and is a medical emergency
American Journal of Health-System Pharmacy, 60(12), 1237-1241
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A considerable number of evidences provided by Sikiric et al
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