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Now it seems oral small-molecule GLP-1s also dial back eating for pleasure by engaging a brain reward circuit. Lorenzo Leggio, clinical director of NIHs National Institute on Drug Abuse, noted the importance of understanding the neural mechanisms as patient uptake increases

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45 Communication between the HPA axis and a brain region known as the amygdala plays a major role manifesting anxiety as a response to stress

Structure Therapeutics GSBR-1290 and Vikings VK2735 join a pipeline of small-molecule orals that promise comparable metabolic benefits with fewer GI events

Implications and Future Directions The pharmacy vs medical benefit structure has profound implications for patient access, health outcomes, and system costs in the context of GLP-1 drugs

GLP-1 Race Heats Up with Positive Test Results for Next-Gen Eli Lilly Drug Approximately one in eight Americans are taking medications like Ozempic or Wegovy for weight loss, diabetes, heart disease and more