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Nauck MA, Meier JJ

2021 NEJM) reported constipation in 23.4% of semaglutide patients vs 9.5% on placebo Why its preferred on semaglutide: PEG works in the colon, not the stomach

WAT mitochondria isolation To isolate mitochondria, fresh gWAT was minced then homogenized using a drill-operated Teflon pestle in ice-cold MSHE buffer (70 mM sucrose, 210 mM mannitol, 5 mM HEPES, 1 mM EDTA, pH 7.2) containing 0.5% FA-free BSA

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While hair loss is not considered a primary side effect of most GLP-1 medications, hair shedding has been reported by some patients

It plays a central role in fat metabolism and energy production