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Data presented herein support the notion that prolonged exposure to GLP-1R stimulation can also induce glucose competence by a secondary mechanism involving up-regulation of glycolytic enzymes, and consequently glycolytic flux, arguably the most important stimulus-secretion coupling factor generating pathway in -cells

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The FDA requires this warning based on animal data, and notes that it is unknown whether these medications cause thyroid C-cell tumors, including medullary thyroid carcinoma, in humans

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