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PT-141 is typically used before anticipated activity and is generally administered at least 45 minutes ahead, since it takes time to reach full effect
A typical loading approach might use 0.75mg to 1mg daily for the first 3 to 5 days, then reduce to 0.5mg for the remainder of the protocol
Csiszar, R
Role of protonmotive force and lipid composition
The reduced expression of pykF in MG12345 led to an increase in the intracellular concentration of PEP and also caused an increase in the concentrations of G6P and F6P, which in turn decreased the glucose uptake rate
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