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Considering this evidence, we hypothesised that activation of the GLP-1 pathway in the OB activates GABAergic neurons in the LH, which inhibit PVN neurons, reducing their stimulation of preganglionic sympathetic neurons

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Patients taking Ozempic who experience hiccups should consider seeking medical advice in the following circumstances: Call 999 or go to A&E if hiccups are accompanied by: Severe abdominal pain (which could indicate pancreatitis or gallbladder disease) Persistent vomiting or inability to keep fluids down Signs of dehydration (reduced urination, dizziness, dry mouth) Difficulty breathing or chest pain Neurological symptoms such as confusion, weakness, or visual changes Call NHS 111 or contact your GP or diabetes care team if: Hiccups persist for more than 48 hours Hiccups are frequent, distressing, or interfering with eating, sleeping, or daily activities You experience worsening gastrointestinal symptoms alongside hiccups You have concerns about whether your symptoms are related to Ozempic Your healthcare provider will take a thorough history and may perform an examination to exclude other causes of persistent hiccups , which can include gastro-oesophageal reflux disease (GORD), gastritis, central nervous system disorders, metabolic disturbances, or medication interactions

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Both medications may need temporary adjustment before surgery, but this is routine for anticoagulation clinics