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Estrogen normally enhances GLP-1 secretion and sensitivity, meaning post-menopausal women may have somewhat blunted natural incretin responses
Therefore, the present findings should not be generalized to females
Characterization of genetic variants of GIPR reveals a contribution of -arrestin to metabolic phenotypes
On the other hand, when injected into the body, specifically in the abdomen, GLP-1 can remain effective for up to 24 hours without being destroyed by the enzyme, allowing it to work continuously to suppress appetite and aid in weight loss
Either way, the principle is the same
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