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This phenomenon induces neuron damage

The Food and Nutrition Board of the National Academy of Sciences recommends a higher dietary allowance (RDA) of vitamin C for smokers (35 mg/day more compared to non-smokers) [8]

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Thus, as far as mitochondrial oxidative stress homeostasis is concerned, mGSH is a vital factor maintaining mitochondrial function, controlling cell survival/death, and its depletion causes cell damage and facilitates cell death [57, 59]

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This persistent state, referred to as anabolic-steroidinduced hypogonadism (ASIH), has been attributed to prolonged suppression of hypothalamic GnRH signalling, desensitisation of pituitary gonadotropes, and potential structural or functional impairment of Leydig cells (79)