glp 1 and dopamine Possible mechanisms by which GLP-1 may reduce alcohol consumption. (A) GLP-1 Receptor Agonists in Mood – Effects of glucagon‐like peptide 1

Rare but serious risks include allergic reactions (including anaphylaxis in very rare cases), liver stress with prolonged high-dose use, and excessive skin lightening with unregulated dosing

Zhu Y, Jameson E, Crosatti M, Schfer H, Rajakumar K, Bugg TD, Chen Y: Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota

Rossini AA, Like AA, Chick WL, Appel MC, Cahill GF Jr

However, continuous therapy is a personal decision involving cost, preference, and medical necessity

Patients not taking additional glucose-lowering medications face lower hypoglycaemia risk, as semaglutide's glucose-dependent mechanism means it primarily works when blood sugar is elevated

2019 Sep 3;11(9):2073