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Role of uptake inhibition and autoreceptor activation in the control of 5-HT release in the frontal cortex and dorsal hippocampus of the rat
Diabetes Obes Metab 24(1):94105 Zaazouee MS et al (2022) Semaglutide for the treatment of type 2 Diabetes Mellitus: A systematic review and network meta-analysis of safety and efficacy outcomes
Samples were separated by SDS-PAGE and transferred to a PVDF membrane (Millipore, Billerica, MA)
The 48 week BELIEVE Phase 2 compared a multiple placebo arm to semaglutide4 (1.0mg or 2.4mg), bimagrumab (10 mg/kg, 30 mg/kg), and sema-bima (1.0mg, 2.4mg semaglutide X 10 mg/kg, 30 mg/kg bimagrumab)
The results: The primary composite (CV death or worsening HF event): 9.9% tirzepatide vs
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