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Cold Spring Harbor Perspectives in Biology , 8 (6), a021899

17,22,32 The findings from these trials suggest that the adverse effects of ibuprofen on the developing lung may potentially exceed the benefits associated with PDA closure and support a shift toward expectant management rather than routine early closure

In a pooled analysis of glycemic control trials with oral semaglutide, diabetic retinopathy complications occurred in 4.2% of T2DM patients receiving semaglutide and 3.8% with comparator

These adaptations may explain why metabolic benefits can continue to improve over weeks to months of consistent use, rather than plateauing immediately