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9 Fang C, Lou DY, Zhou LQ, et al
Many therapeutic peptides require injection, so an orally active candidate is of particular research interest
Therapeutic limitations imposed by rapid phase II metabolism have motivated the development of C-4- and C-8-substituted compounds via the von Pechmann and Mannich reactions
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Bacteriostatic water contains 0.9% benzyl alcohol, which inhibits bacterial growth for up to 28 days and is the required solvent for multi-dose peptide reconstitution
Concerning reactions include: spreading redness beyond a 2-inch radius from the injection point (possible cellulitis), warmth that persists beyond 24 hours with worsening tenderness (possible abscess formation), pus or cloudy discharge from the injection site (infection), red streaks extending from the site toward the torso (lymphangitis), or systemic symptoms like fever above 100.4F within 48 hours of injection
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