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Johnston-MacAnanny, M.D

393 Studies indicate that a lack of SIRT6 leads to reduced mitochondrial gene expression, increased production of ROS, and accelerated mitochondrial decay, collectively triggering mitochondrial dysfunction

Timing: Pre- vs Post-Training IGF-1 LR3 administered 1530 minutes post-resistance training capitalizes on exercise-induced muscle damage and elevated muscle protein synthesis rates, which persist for 2448 hours after training

Drug Class: CNS Stimulant, Indirectly Acting Sympathomimetic Background Chemistry: Amphetamines are synthetic indirectly acting sympathomimetic agents that are structurally related to the naturally occurring stimulant ephedrine

Pharmaceuticals that stimulate these pathways may alleviate chondrocyte ferroptosis and slow the course of OA