But if this factor is taken into account, the doses humans were given in the pilot study still exceed those that have been tested in animals
Furthermore, roGFP2 fusion constructs with wild-type and mutant enzymes allow the intracellular analysis of enzyme mechanisms and structure-function relationships 15,34,35,75
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Previous research identified mitochondrial dysfunction as a key driver of ROS in early DR, with targeted antioxidants showing promise in preclinical models (53)
doi:10.3810/pgm.2008.09.1909