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The Summary of Product Characteristics for Mounjaro (tirzepatide) explains that tirzepatide has the potential to impact the rate of absorption of concomitantly administered oral medicinal products and that the impact is most pronounced at the time of tirzepatide treatment initiation. The tirzepatide Patient Information Leaflet advises that if you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine. While Ozempic and Wegovy contain semaglutide and work by mimicking a hormone called GLP-1 that triggers an increase in the production of insulin, Mounjaro contains the active ingredient tirzepatide, and also acts on a second hormone involved in appetite and blood sugar control
Therefore, the design, discovery, and development of short and long-acting peptide-based GLP-1RAs, including small-molecule agonists are desirable for therapeutic applications beyond T2DM
Access and Regulatory Status Both peptides face an evolving regulatory environment
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