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The glucose-dependent insulinotropic polypeptide receptor adds a second layer of metabolic regulation that amplifies fat oxidation, improves lipid metabolism, and appears to enhance the weight loss effects beyond what GLP-1 activation alone can achieve
Although these drugs have been used to treat type 2 diabetes for nearly two decades, it was not until 2021 that the US FDA approved them for treating obesity
O'Connor et al., 2015
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A 2025 review found tirzepatide at 15 mg weekly produced weight loss of up to 17.8% over 72 weeks (PubMed)
These combined effects create a multi-vector approach to skin remodeling that few other peptides can replicate
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