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Metformin and the gastrointestinal tract

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Wegovy now goes up to 7.2mg, but we don't yet have data on whether this changes the picture

In addition to release of PRR ligands, hepatocyte stress and death are associated with release of pro-inflammatory cytokines, including inflammasome-mediated interleukin-1 (IL-1), which further contributes to NASH-associated hepatitis (171)