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10.1016/j.jneuroim.2008.09.005

This is because the enzyme is working too fast in its conversion

CAMARADES was the methodological quality assessment tool

In educational frameworks, DSIP is positioned at most for the patient with documented, persistent sleep-architecture problems who has genuinely failed sleep hygiene, CBT-I, and melatonin, and who explicitly understands they would be engaging with something investigational rather than a validated treatment