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Y1135 (being the first tyrosine to be phosphorylated after stimulation with ligand) in the a-loop is bound in cis position in the active site, thus preventing the substrate access and occluding the ATP binding site as well

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This reduction step occurs via oxidation of GSH to GSSG, and the GSSG is subsequently reduced back to GSH in the body via the enzyme glutathione reductase and NADPH 591

Several different health problems are strongly correlated with low glutathione

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