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noted reduced expression of the GHR in the kidneys of 5/6 nephrectomized animals, which was associated with elevated pro-inflammatory cytokines, suggesting that GH-insensitivity in uremia is a general phenomenon and not restricted to the liver and growth plates ( vide supra ) [174]

Brenke JK et al

There are several benefits of vitamin C, one of which is its role in collagen production